The process is the key to models of lung injury in which catecholamines alter sodium and fluid transport. Sartori et al. hypothesized that a beta-adrenergic agonist such as salmeterol, commonly used in the treatment of asthma, may favorably alter the defective alveolar fluid and sodium clearance. They showed that in susceptible mountaineers pretreated with inhaled salmeterol, the incidence of high-altitude pulmonary edema decreased 50% compared with control subjects.

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