V. PERSPECTIVE AND RESEARCH IMPLICATIONS
High-altitude pulmonary edema is preventable. Fortu¬nately, very few mountain climbers are susceptible, but those who are may have unpredictable recurrences when they are exposed to high altitudes. The susceptible individual must take prophylaxis including acetazolamide, nifedipine, inhaled salmeterol; ascend slowly; and avoid vigorous exertion. Considerable research is required in this area to further clarify the pathogenesis of high-altitude cerebral edema. This research would help refine more beneficial treatment. Natural products including Ginkgo biloba and garlic may be useful for the amelioration of benign symptoms of high-altitude illness. Drugs including sildenafil, which inhibits hypoxemia-induced pulmonary hypertension, may be useful in the management of high-altitude pulmonary edema and are being studied.