I. ABDOMINAL AORTIC ANEURYSM
This repair succeeds in excluding the aneurysm from circulation while allowing blood to flow through the prosthetic stent graft lumen to the distal aorta and iliac vessels to the legs. This represents a major breakthrough because many patients with aneurysms are elderly and have other diseases, particularly prior heart attacks and heart failure, which carry an increased risk for major surgical intervention.
Unfortunately, less than 50% of patients have aneurysm anatomy that is suitable for endovascular grafts. More than 90% of females are rejected because of anatomical criteria that include a smaller iliac artery diameter and aortic pathology, but the more common criteria is encroachment of the aneurysm on the renal arteries. In addition, there are several problems encountered that include a high incidence of endovascular leaks and approximately 5% of patients have aneurysms that continue to grow; 1% of patients may go on to rupture their aneurysm.
Many devices have been introduced and have become obsolete within a couple of years because no engineer or manufacturer has been able to resolve the issue of endoleaks. Also biomaterial failure because of poor graft design leading to stent fractures, graft limb thrombosis, and iliac limb dislodgment may occur in modular grafts. The FDA issued a public health warning because of serious adverse events that occurred with approved products in 2002; a similar warning was given in the UK.
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