Chemotherapeutic agents — The chemotherapeutic agent 5-fluorouracil is known to cause coronary artery spasm in some patients that may lead to symptoms of angina and occasionally myocardial infarction (see the chapter Chemotherapy-Induced Heart Disease).
Syndrome X — This rare syndrome appears to affect mainly women, and in these patients angina-like symp¬toms may occur in the presence of normal coronary arteries. There is no evidence of obstruction or spasm in these patients, and the exact cause for pain remains obscure.

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