Nitroglycerin tablets will work best if the lower half of the body is kept much lower than the head, that is, it is better to sit than to lie flat after taking them. You may remain propped up in bed. Nitroglycerin causes expansion or dilatation of the blood vessels in the scalp, and this effect may produce a headache. The headache is not due to an increase in blood pressure; in fact, nitroglycerin dilates the arteries slightly and this causes a small fall in blood pressure. Therefore, be careful not to take more than two doses of nitroglycerin and not to walk right away. Unless you are accustomed to the dosage, you may become dizzy or feel faint and fall.
Nitrate tablets that are swallowed are the oldest preparations available in the treatment of angina. These drugs are low in cost and have no serious side effects. They cause frequent headaches, however, and are less effective than beta-blockers.

Supplied: Sublingual nitroglycerin tablets: 0.15 mg, 0.3 mg, and 0.6 mg. Sublingual glyceryl trinitrate tablets: 300 mg, 500 mg, and 600 mg. Also available as Nitrolingual spray.
Dosage: Patients are usually advised to start with 0.3 mg. The tablet is placed under the tongue with the patient seated. The drug will not be as effective if the patient is lying down, and if the patient is standing, dizziness or faintness may occur. Thereafter, the usual prescribed dose is 0.3 mg or 0.6 mg of nitroglycerin or 500–600 mg of glyceryl trinitrate.

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