5. ACE inhibitors inhibit vascular superoxide production, and because superoxide reacts with nitric NO, ACE inhibitors appear to increase NO bioactivity. This action, although modest, is important in patients with coronary artery disease (CAD).
6. The modulation and adequacy of the neurohormonal response to the long-term administration of ACE inhibitors in heart failure appear to be associated with ACE gene polymorphism. Patients with heart failure and aldosterone escape have been shown to have a higher prevalence of DD genotype compared with patients who have normal aldosterone levels. A small study indicated that the antihypertensive response to ACE inhibition is more pronounced in subjects with ACE DD genotype than in those with ACE II genotype. 7. The ACE inhibitor captopril has been shown to modestly reduce high blood uric acid levels. This action may be important in an individual who is given diuretics that increase uric acid levels. Captopril may counteract some of this adverse effect.
B. Available ACE inhibitors
Below is a list of available ACE inhibitors.
1. Captopril — dosage 12.5–50 mg two or three times daily for hypertension and heart failure. The discovery of captopril, the first ACE inhibitor used in clinical practice, provided a major change in the management of heart failure.

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