These naturally derived products from several sources including red grape juice, red wine, soy products, and nuts (particularly almonds, walnuts, and hazel nuts), are receiving attention for their antioxidant and cardioprotec-tive properties.
A. Purple Grape Juice
1. Freedman et al. Study
Methods: The effect of purple grape juice supplementa¬tion was assessed in vivo in 20 healthy subjects. Welch’s grape juice, 7 ml/kg, was administered for 14 days and used on isolated platelet preparations. Major polyphenolic compounds in purple grape juice were isolated and separated into four classes: flavonols (quercetin), cinnamic acids, anthocyanins, and polyflavan-3-ols (tannins).
Results: Incubation of platelets with purple grape juice led to reduced dependent inhibition of adenosine diphosphate induced aggregation and a dose-dependent decrease in superoxide release, which was associated with an increase in platelet NO production. Similar in vivo findings occurred following two weeks of purple grape juice consumption. Plasma antioxidant activity increased by 50%.
Conclusion: Both oral supplementation and in vitro incubation with purple grape juice decreases platelet
aggregation, increases platelet-derived NO, and decreases superoxide production. The suppression of platelet-mediated thrombosis represents a potential mechanism for the beneficial effects of purple grape products, inde¬pendent of alcohol consumption.

Клиника артрит. Улица Горчакова.