2. Platelet activation: The smooth discoid platelet assumes a spiculated form, thus increasing the surface area of the platelet membrane where thrombin is gen¬erated. Figure 1 illustrates the complex and orchestrated processes that lead to platelet aggregation along with stimulatory and inhibitory drugs and substances.
3. Platelet aggregation: Platelet activation converts the glycoprotein IIb/IIIa receptor into a form that can bind fibrinogen and aggregation occurs.

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