6. Homocysteine
There has been much talk in the past decade about the influence of elevated plasma homocysteine, atheroma formation and risk for cardiac events. The evidence linking elevated homocysteine levels and atherosclerosis is indeed weak. In a randomized clinical trial the administration of pyridoxine and folic acid caused a reduction of homo-cysteine levels, but resulted in a greater number of occlu¬sions to intracoronary stents. In the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial reduction of total homocysteine after nondisabling cerebral infarction had no effect on vascular outcomes during the 2 years of follow up.

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