V. CLINICAL STUDIES
A. Maehara et al.
Study question: What are the clinical and angiographic correlates of plaque rupture detected by intravascular ultrasound?
Methods: Three hundred plaque ruptures in 254 patients were assessed by angiographic and intravascular ultrasound.
Results: Plaque rupture occurred in 46% of patients with unstable angina and 33% of patient with myocardial infarction, but it was also observed in 11% of patients with stable angina and 11% of patients with no symptoms. The tear the fibrous cap occurred at the shoulder in 63% and occurred in 37% in the center of the plaque. Thrombi were common in patients with unstable angina. The plaque rupture site contained the minimum lumen area site in only 28% of patients; rupture sites had larger arterial and luminal areas and more positive remodeling than minimum luminal area sites.
Conclusions: Surprisingly, plaque ruptures usually do not cause lumen compromise.
B. Varnava et al.
Study question: Is there a relationship between the mor¬phologic characteristics of coronary plaque vulnerability, lipid core size, and macrophage count, and coronary artery positive remodeling (no lumen narrowing), or increased constrictive adventitial fibrosis and thickening with nega¬tive remodeling (lumen narrowing)?
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