This relatively cardioselective, partially hydrophilic and lipophilic agent possesses mild beta-agonist activity. A dosage of 200–300 mg twice daily is given for hyper¬tension. Because of the presence of beta-agonist activity, this drug is not indicated for the management of angina or myocardial infarction.
B. Atenolol
This beta-1 cardioselective agent is water-soluble, hydro-philic, and eliminated by the kidneys. It has a low side effect profile and is therefore widely used. As outlined above, the drug has not been shown to decrease mortality in randomized trials. A dosage of 25–50 mg once daily is given, but a dose of 75 mg is required in some patients with angina or hypertension.
C. Bisoprolol
This agent is highly beta-1 selective and is more car-dioselective than metoprolol and atenolol. It is 50% lipophilic and metabolized in the liver. The water-soluble, hydrophilic component is excreted by the kidneys. The concentration of unchanged bisoprolol in rat brain is lower than that of metoprolol or propranolol, but higher than that of atenolol after dosing. This agent has a low side effect profile. A dosage of 5–10 mg once daily, and a maximum of 15 mg daily is recommended.
D. Carvedilol

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