B. Study by Labarrere et al.
This study showed that heart transplant recipients with high concentrations of CRP have more severe and more rapid progression of coronary artery disease in the transplant. In addition, this finding was associated with a high expression of endothelial intracellular adhesion molecule-I (ICAM-I) and high concentrations of ICAM-I in serum. Eisenberg et al. found that the rise in CRP levels in nine consecutive cardiac transplant patients signifi¬cantly predicted graft failure. At 10-year follow up there was a significant reduction of allograft survival in patients with high CRP. Immune mechanisms have been postulated because only the vessels of the allograft were involved with accelerated atherosclerosis sparing the host’s native arteries.
C. Study by Danesh et al.
This large, well-conducted study concluded that ele¬vated levels of C-reactive protein are associated with only a moderate increase in the risk of coronary heart disease.

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