Patients with heart disease or cardiovascular disease with LDL cholesterol levels greater than 2.5 mmol/L are recommended to receive a statin to maintain a goal of less than 2.5 mmol/L. The treatment with statins has been shown to reduce CRP levels.
Patients at high risk: acute coronary syndrome, should achieve LDL goal of less 80 mg/dl (2 mmol/l) and CRP levels lowered to normal regardless of LDL levels. Ridker et al. indicate that CRP monitoring should be used in patients with acute coronary syndrome to assess risk; patients who have low CRP levels after statin therapy appear to have better clinical outcomes than those with higher CRP levels regardless of the level of LDL achieved.

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