The phenol chlorogenic acid reduces glucose absorp¬tion and oxidative stress in vitro and inhibits hydrolysis of glucose-6-phosphate, which could reduce glucose output in the liver. Coffee contains substantial amounts of magnesium that could improve insulin sensitivity and insulin secretion and has been associated with a lower risk of type 2 diabetes. The epidemic of diabetes worldwide continues and any strategy that can be added to the armamentarium to prevent diabetes would be welcome.
1. Clinical Study: van Dam et al.
van Dam investigated the association between coffee con¬sumption and risk of clinical type 2 diabetes in 17,111 Dutch men and women aged 50–60. During 125,774 person-years of follow up, 306 new cases of type 2 diabetes were reported.
After adjustment for potential confounders, individuals who drank at least 7 cups of coffee daily were 0.05 times as likely as those who drank 2 cups of coffee daily to develop type 2 diabetes ( p ¼ 0.0002). Higher coffee consumption was associated with a lower risk of type 2 diabetes.
It is known that caffeine acutely lowers insulin sen¬sitivity. In a small intervention study, increased coffee consumption for two weeks reduced fasting blood glucose, whereas the substitution of decaffeinated coffee for caf-feinated coffee for 3 weeks did not affect blood glucose.

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