• In patients with stable angina the addition of a calcium antagonist, particularly a dihydropyridine or diltiazem, has been shown in clinical trials to cause significant amelioration of recurrent chest pain.
In patients with severe aortic regurgitation, the unloading effect of nifedipine has been shown in a clinical trial to cause significant reversal of the left ventricular dilatation and hypertrophy, and surgi¬cal therapy may be appropriately delayed from 1 to 2 years.
Patients with cold fingers and Raynaud’s phenomenon may find some benefit with calcium antagonists. The dihydropyridine nimodipine, in a clinical trial, was shown to be useful in the management of cerebral arterial spasm caused by subarachnoid hemorrhage with controlled blood pressure.
Following coronary artery bypass graft using the radial artery as a conduit, dihydropyridine calcium antago¬nists are used for an indefinite period to prevent spasm and occlusion of the arterial graft.

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