A. Based on LDL Cholesterol
A high LDL cholesterol level is considered the most important major risk factor for coronary artery disease. The relationship between LDL cholesterol and coronary artery disease risk is continuous over a broad range of blood levels from low to high (110 mg/dl to greater than 190 mg/dl) and LDL cholesterol is the primary target of therapy.
Patients with established coronary artery disease are considered to have a 10-year risk greater than 20%. It is expected that more than 20% of such individuals will develop a recurrent coronary artery disease event within 10 years. In these individuals LDL cholesterol levels greater than 130 mg/dl greatly increase the risk. Most national guidelines state that in patients with proven coronary artery disease or CAD risk equivalent, particularly diabetes, drug treatment is strongly indicated to main¬tain the level to less than 100 mg/dl (2.6 mmol/L) (see Table 2). This author advises a level less than 80 mg/dl (2 mmol/dl).
individuals without coronary artery disease or evidence of cardiovascular disease should be assigned a risk based on the following:
1. Their levels of LDL cholesterol: risk is increased if the LDL-C is >190 mg/dl, and the goal should be < 130 mg/dl (3.5 mmol/L)

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