Deficiencies in the xenobiotic-metabolizing P-450s are associated with clinical drug oxidation polymorphisms which result in toxic reactions to several prescription drugs. Table 1 gives a list of human P-450s, the tissues in which they are expressed, and some of their substrates. Figure 1 gives the substrates for CYP2D6 which include the commonly used beta-adrenergic blocking and antiarrhyth-mic agents.

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