A. van Dam et al.
Study question: Metabolic studies indicate that caffeine acutely decreases sensitivity to insulin, but tolerance to caffeine can develop. Chlorogenic acid, a phenol, reduces glucose absorption and oxidative stress and inhibits hydro¬lysis of glucose-6-phosphate that could reduce glucose output in the liver. Can coffee consumption decrease the risk of type 2 diabetes?
Methods: Investigation of 17,111 Dutch men and women aged 30–60.
Results: During 125,774 person-years of follow up, 386 new cases of type 2 diabetes were reported. Individuals who drank at least seven cups of coffee daily were 0.50 times as likely as those who drank two cups daily to develop type 2 diabetes (P ¼ 0.0002).
Conclusion: Coffee consumption was associated with a substantially lower risk of clinical type 2 diabetes.