Study question: To define the relationship between body mass index and insulin resistance in 314 nondiabetic, normotensive healthy volunteers.
Methods: ‘‘Insulin resistance was quantified by deter¬mining the steady-state plasma glucose concentration during the last 30 min of a 180-min infusion of octreotide, glucose, and insulin.
Results: The body mass index and steady-state plasma glucose were significantly related.
Conclusions: Insulin resistance at any given degree of obesity appears to accentuate the risk of coronary heart disease and type 2 diabetes.
B. Other Studies
A research study of interest indicates that both abnormal pteridine metabolism and vascular oxidative stress are linked to coronary endothelial dysfunction in the insulin resistance subject.
In the Western Scotland Coronary Prevention Study of 5974 men, 2.6% of these men aged 45–64 developed type 2 diabetes. A 30% risk reduction for diabetes was observed among pravastatin users.
In the United Kingdom Prospective Diabetes Group Study the efficacy of intensive glucose control using a complex protocol with either insulin or sulfonylureas compared with conventional treatment failed to demon¬strate definite clinical benefit in macrovascular complica¬tions in patients with type 2 diabetes.

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