Nearly all patients with valvular lesions who discon¬tinued the drugs had no progression of lesions and some even showed signs of regression. Only one of the original patients described required valve surgery.
B. Perspective and Research Implications
The problems that afflict overweight individuals will not disappear. In fact the prevalence of obesity is increasing and becoming an insurmountable problem in North America. There must be a continued search for anorectic drugs that are as important for millions of individuals as the elixir of life. Researchers should be able to find suitable agents that are devoid of cardiac or cardiovascular side effects. It is obvious that agents that involve the serotonin pathway would be expected to cause cardiac lesions. This is a fruitful area of research that can help millions of individuals worldwide.

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