Obesity is a risk factor for CAD, diabetes, and hyperten¬sion. Weight-reduction diets assist less than 25% of obese individuals; a return of weight gain is common, often within months of ending the diet that is difficult to adhere to for several years. For the past 50 years drugs have been sought to decrease appetite and food intake that results in significant weight loss. Most anorectic agents disappear from the market after 1–5 years because of adverse effects and adverse publicity. The drug phentermine (phen-fen) was approved in United States in 1959. This noradre-nergic agent was soon lost. Fenfluramine, a sympathomi-metic amine that activates the serotonergic pathways in the brain to induce its anorectic effects, and fenfluramine, the D-isomer of fenfluramine, were approved in 1973 and 1996, respectively. The combination of fenfluramine and phentermine appeared more efficacious than monotherapy, and it was widely prescribed from 1995 to 1998 to about 4.6 million individuals in the United States.

TABLE 1
Trans Fatty Acid Content of Some Popular Processed Foods
Prepared in Restaurants and Fast Food Outlets (any serving
containing >0.5 g is considered excessive)
Product
Serving size
Trans fatty acid (~g/serving)

Страницы: 1 | 2 | 3