Patients who tested positive for T-wave alternans were approximately 10 times more likely to have a cardiac arrest or to become a victim of sudden cardiac death than patients with a negative test. In the MADIT II clinical trial, T-wave alternans positive patients had a 15% mortality versus 7% for the entire MADIT II subgroup. There were no deaths among T-wave alternans negative patients. This study suggests that T-wave alternans positive patients will obtain a greater mortality benefit from an implantable converter defibrillator.

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