c. Lisinopril (Zestril, Prinivil, Carace)
Supplied: Tablets: 5 mg, 10 mg, 20 mg. Dosage: 2.5 mg once daily increasing as needed to main¬tenance of 20–40 mg daily. Table 2 gives the names and dosage of ACE inhibitors and ARBs.
D. Angiotensin receptor blockers
ARBs specifically block the angiotensin II receptor AT1, and this causes a blockade of the renin-angiotensin-aldosterone system. Although, as with ACE inhibitors, the blockade is not compete. Because angiotensin can be synthesized outside of the renin-angiotensin system, ARBs could produce more effective control of angiotensin II than ACE inhibitors and have the potential to be more effective antihypertensive and heart failure agents. In addition they do not cause a dry cough or life-threatening angioedema like ACE inhibitors. The ARB, candesartan, demonstrates long-lasting blockade of the AT1 receptor and appears to have the most potent blood pressure lower¬ing effects in the ARB class.
d. Candesartan (Atacand Amias)
Supplied: 4 mg, 8 mg, 16 mg, 32 mg.
Dosage: Initial 4–8 mg titrated to 16–32 mg once daily.
e. Irbesartan (Avapro, Aprovel)
Supplied: 75 mg, 150 mg, 300 mg.
Dosage: 150–300 mg daily. Elderly: initial 75 mg.
Only the 300-mg dose has been shown to be effective in causing some degree of renal protection and reduc¬tion of microalbuminuria. See the chapter Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers for other agents of this class.

Страницы: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15