A. Danshen (Salvia miltiorrhiza)
Danshen is believed to possess vasoactive, free radical scavenger, and demonstrable antiplatelet properties. It is widely used in China for the management of angina and acute myocardial infarction. The active substances of Danshen are phenolics and tanshinones, which cause generalized dilatation of arteries and thus decreases blood pressure. But at high doses it causes vasoconstriction in noncoronary arteries. This substance has no inotropic effect, and does not increase cardiac contractility. The possibility of coronary artery vasodilatation with Danshen requires further investigation.
1. Benefits and Adverse Reactions
Transhinone, in a double-blind study of 67 patients with coronary artery disease, produced symptomatic and electrocardiographic benefits. A decrease in the clearance of warfarin and increased bioavailability may cause bleeding in this substance.
B. Ephedra sinica (Ma Huang)
The active constituent in this herbal medicine is ephedrine, a known stimulant that possesses strong sympathomimetic activity with properties similar to epinephrine.
shows that the molecular structure of ephedrine is similar to that of amphetamine and the related ephedra alkaloid and metabolite, phenylpropranolamine. The latter is found commonly in nasal sprays and in cough mixtures, and has recently (in 2000) been removed from products because of warnings from the FDA, Health Canada, and other health authorities.

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