Gamma butyrolactone has been eliminated from products in the United States because of an FDA warning in 1999 to manufacturers. This warning was made because there was a report of more than 55 cases of adverse reactions including coma that required artificial ventilatory support. The coma occurred in a professional basketball player who ingested the substance to aid in sleep and help muscle growth. Gamma butyrolactone is metabolized into gamma-hydroxybutyrate, which is known to cause seizures and coma.

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